Drug interactions
Fosinopril-hydrochlorothiazide + Porfimer
Severity: Moderate
Fosinopril-hydrochlorothiazide and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Porfimer is a photosensitizer used in photodynamic therapy, and hydrochlorothiazide is itself a photosensitizing drug. Combining them may increase the risk or severity of phototoxic skin reactions after light exposure.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosinopril-hydrochlorothiazide belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Additive photosensitizing effects of the two agents.
What to do
Counsel strict avoidance of sunlight and bright indoor light for the period specified in the porfimer labeling, and consider whether the thiazide can be temporarily replaced by a non-photosensitizing antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Porfimer
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Porfimer?
MediHelp rates the interaction as moderate. Fosinopril-hydrochlorothiazide and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Porfimer is a photosensitizer used in photodynamic therapy, and hydrochlorothiazide is itself a photosensitizing drug. Combining them may increase the risk or severity of phototoxic skin reactions after light exposure.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict avoidance of sunlight and bright indoor light for the period specified in the porfimer labeling, and consider whether the thiazide can be temporarily replaced by a non-photosensitizing antihypertensive.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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