Drug interactions
Furosemide + Liothyronine
Severity: Minor
Furosemide and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High doses of furosemide, particularly intravenous, can displace thyroid hormones from binding proteins and transiently raise free hormone levels. Total thyroid hormone measurements may then fall, which can complicate interpretation of thyroid function tests. Clinically significant effects are uncommon.
What this interaction means in plain words
Furosemide and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Furosemide belongs to Cardiovascular; Liothyronine belongs to Endocrine.
Why it happens
Furosemide displaces thyroid hormone from plasma protein binding sites, altering free and total concentrations.
What to do
Interpret thyroid function tests cautiously in patients on high-dose furosemide, and assess clinical status along with free hormone levels before changing liothyronine dosage.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Furosemide with Liothyronine?
MediHelp rates the interaction as minor. Furosemide and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High doses of furosemide, particularly intravenous, can displace thyroid hormones from binding proteins and transiently raise free hormone levels. Total thyroid hormone measurements may then fall, which can complicate interpretation of thyroid function tests. Clinically significant effects are uncommon.
How serious is the interaction between Furosemide and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Interpret thyroid function tests cautiously in patients on high-dose furosemide, and assess clinical status along with free hormone levels before changing liothyronine dosage.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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