Drug interactions
Furosemide + Magnesium sulphate
Severity: Moderate
Furosemide and Magnesium sulphate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics increase urinary magnesium loss and can cause hypomagnesemia. This can partly offset magnesium supplementation and, when magnesium is given for repletion or eclampsia prophylaxis, may lower the achieved serum level. Electrolyte disturbances may also raise arrhythmia risk.
What this interaction means in plain words
Furosemide and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Magnesium sulphate belongs to Cardiovascular.
Why it happens
Furosemide inhibits Na-K-2Cl transport in the thick ascending limb, reducing paracellular magnesium reabsorption and increasing renal excretion.
What to do
Monitor serum magnesium, potassium and calcium during combined use and adjust magnesium dosing to the measured level. Replace magnesium as needed in patients on long-term loop diuretics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Magnesium sulphate?
MediHelp rates the interaction as moderate. Furosemide and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics increase urinary magnesium loss and can cause hypomagnesemia. This can partly offset magnesium supplementation and, when magnesium is given for repletion or eclampsia prophylaxis, may lower the achieved serum level. Electrolyte disturbances may also raise arrhythmia risk.
How serious is the interaction between Furosemide and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium, potassium and calcium during combined use and adjust magnesium dosing to the measured level. Replace magnesium as needed in patients on long-term loop diuretics.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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