Drug interactions
Furosemide + Sucralfate
Severity: Moderate
Furosemide and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate binds oral furosemide in the gut and reduces its absorption, which can blunt diuretic and antihypertensive effect. The effect is relevant only when both are taken by mouth at the same time.
What this interaction means in plain words
Furosemide and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Adsorption or binding of furosemide in the gastrointestinal tract by sucralfate, decreasing absorption.
What to do
Separate oral furosemide and sucralfate by at least 2 hours, taking furosemide first. Monitor urine output, weight and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Sucralfate?
MediHelp rates the interaction as moderate. Furosemide and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate binds oral furosemide in the gut and reduces its absorption, which can blunt diuretic and antihypertensive effect. The effect is relevant only when both are taken by mouth at the same time.
How serious is the interaction between Furosemide and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral furosemide and sucralfate by at least 2 hours, taking furosemide first. Monitor urine output, weight and blood pressure.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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