Drug interactions
Gemfibrozil + Glipizide
Severity: Moderate
Gemfibrozil and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may potentiate the hypoglycemic effect of glipizide. The proposed explanation is reduced clearance of the sulfonylurea and displacement from plasma proteins. The clinical effect is generally modest but can matter in frail patients or those with poor intake.
What this interaction means in plain words
Gemfibrozil and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Glipizide belongs to Endocrine.
Why it happens
Possible CYP2C9 inhibition and protein-binding displacement, adding to the glucose-lowering effect of the sulfonylurea.
What to do
Check blood glucose more often after starting or stopping gemfibrozil. Lower the glipizide dose if hypoglycemic symptoms or low readings appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Glipizide
Frequently asked questions
Can I take Gemfibrozil with Glipizide?
MediHelp rates the interaction as moderate. Gemfibrozil and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may potentiate the hypoglycemic effect of glipizide. The proposed explanation is reduced clearance of the sulfonylurea and displacement from plasma proteins. The clinical effect is generally modest but can matter in frail patients or those with poor intake.
How serious is the interaction between Gemfibrozil and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after starting or stopping gemfibrozil. Lower the glipizide dose if hypoglycemic symptoms or low readings appear.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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