Drug interactions
Gemfibrozil + Lacosamide
Severity: Minor
Gemfibrozil and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil inhibits CYP2C9 and CYP2C19, which contribute to lacosamide metabolism, so lacosamide exposure may rise slightly. Lacosamide has multiple elimination routes, so the effect is expected to be modest, but dose-related dizziness, ataxia or PR interval prolongation could become more likely.
What this interaction means in plain words
Gemfibrozil and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gemfibrozil belongs to Cardiovascular; Lacosamide belongs to Central Nervous System.
Why it happens
Gemfibrozil inhibits CYP2C9/CYP2C19-mediated O-demethylation of lacosamide, modestly reducing its clearance.
What to do
No routine dose change is needed; monitor for dizziness, somnolence and cardiac conduction effects when gemfibrozil is started. Reduce the lacosamide dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Gemfibrozil with Lacosamide?
MediHelp rates the interaction as minor. Gemfibrozil and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gemfibrozil inhibits CYP2C9 and CYP2C19, which contribute to lacosamide metabolism, so lacosamide exposure may rise slightly. Lacosamide has multiple elimination routes, so the effect is expected to be modest, but dose-related dizziness, ataxia or PR interval prolongation could become more likely.
How serious is the interaction between Gemfibrozil and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for dizziness, somnolence and cardiac conduction effects when gemfibrozil is started. Reduce the lacosamide dose if adverse effects appear.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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