Drug interactions
Gemfibrozil + Vadadustat
Severity: Moderate
Gemfibrozil and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil may increase vadadustat exposure. This can produce an excessive or rapid hemoglobin rise and increase adverse effects such as thrombotic events and hypertension.
What this interaction means in plain words
Gemfibrozil and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated renal transport and possibly glucuronidation of vadadustat by gemfibrozil.
What to do
Monitor hemoglobin regularly and adjust the vadadustat dose per hemoglobin response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Gemfibrozil with Vadadustat?
MediHelp rates the interaction as moderate. Gemfibrozil and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil may increase vadadustat exposure. This can produce an excessive or rapid hemoglobin rise and increase adverse effects such as thrombotic events and hypertension.
How serious is the interaction between Gemfibrozil and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and adjust the vadadustat dose per hemoglobin response.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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