Drug interactions
Gemifloxacin + Leuprolide
Severity: Moderate
Gemifloxacin and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and gemifloxacin has similar effects. Combined use may increase the risk of torsades de pointes, particularly with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Gemifloxacin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemifloxacin belongs to Anti Bacterial; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation; testosterone suppression alters cardiac repolarization while gemifloxacin blocks hERG channels.
What to do
Review other QT-prolonging drugs and correct potassium and magnesium. Obtain an ECG in patients with cardiac risk factors, or choose a non-QT-prolonging antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Gemifloxacin with Leuprolide?
MediHelp rates the interaction as moderate. Gemifloxacin and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide can prolong the QT interval, and gemifloxacin has similar effects. Combined use may increase the risk of torsades de pointes, particularly with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Gemifloxacin and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review other QT-prolonging drugs and correct potassium and magnesium. Obtain an ECG in patients with cardiac risk factors, or choose a non-QT-prolonging antibiotic.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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