Drug interactions
Gepirone + Hydroxychloroquine
Severity: Major
Gepirone and Hydroxychloroquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both hydroxychloroquine and gepirone can prolong the QT interval, so combining them adds to the risk of torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or existing heart disease. Gepirone labeling carries QT-related cautions.
What this interaction means in plain words
Gepirone and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gepirone belongs to Central Nervous System; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the combination in patients with long QT or other risk factors, and monitor QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Hydroxychloroquine?
MediHelp rates the interaction as major. Gepirone and Hydroxychloroquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both hydroxychloroquine and gepirone can prolong the QT interval, so combining them adds to the risk of torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or existing heart disease. Gepirone labeling carries QT-related cautions.
How serious is the interaction between Gepirone and Hydroxychloroquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Avoid the combination in patients with long QT or other risk factors, and monitor QTc.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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