Drug interactions
Gepirone + Indacaterol
Severity: Moderate
Gepirone and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone prolongs the QT interval and indacaterol, a long-acting beta-2 agonist, can also affect QTc and cause tachycardia and hypokalemia. Used together they may add to the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Gepirone and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gepirone belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive QTc prolongation through pharmacodynamic effects, with possible beta-agonist-induced hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use. Correct electrolyte abnormalities and avoid the combination in patients with congenital long QT syndrome or other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Gepirone with Indacaterol?
MediHelp rates the interaction as moderate. Gepirone and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gepirone prolongs the QT interval and indacaterol, a long-acting beta-2 agonist, can also affect QTc and cause tachycardia and hypokalemia. Used together they may add to the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Gepirone and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use. Correct electrolyte abnormalities and avoid the combination in patients with congenital long QT syndrome or other QT risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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