Drug interactions
Givosiran + Maprotiline
Severity: Moderate
Givosiran and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, which may raise maprotiline concentrations. Higher levels increase the risk of seizures, arrhythmia and anticholinergic effects.
What this interaction means in plain words
Givosiran and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Maprotiline belongs to Central Nervous System.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing maprotiline metabolism.
What to do
Consider reducing the maprotiline dose and monitor for adverse effects such as sedation, anticholinergic effects and ECG changes. Use an alternative antidepressant if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Maprotiline?
MediHelp rates the interaction as moderate. Givosiran and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, which may raise maprotiline concentrations. Higher levels increase the risk of seizures, arrhythmia and anticholinergic effects.
How serious is the interaction between Givosiran and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the maprotiline dose and monitor for adverse effects such as sedation, anticholinergic effects and ECG changes. Use an alternative antidepressant if tolerability is poor.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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