Drug interactions
Givosiran + Ramelteon
Severity: Moderate
Givosiran and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and ramelteon is mainly cleared by CYP1A2. Ramelteon exposure may therefore rise, increasing sedation, dizziness and next-day impairment.
What this interaction means in plain words
Givosiran and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givosiran belongs to Miscellaneous; Ramelteon belongs to Central Nervous System.
Why it happens
Givosiran inhibits CYP1A2, reducing the metabolism of ramelteon.
What to do
Monitor for excess sedation and consider a lower ramelteon dose or an alternative hypnotic that does not rely on CYP1A2. Reassess if ramelteon effects become excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Ramelteon?
MediHelp rates the interaction as moderate. Givosiran and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and ramelteon is mainly cleared by CYP1A2. Ramelteon exposure may therefore rise, increasing sedation, dizziness and next-day impairment.
How serious is the interaction between Givosiran and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider a lower ramelteon dose or an alternative hypnotic that does not rely on CYP1A2. Reassess if ramelteon effects become excessive.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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