Drug interactions
Givosiran + Sertraline
Severity: Minor
Givosiran and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity and raise exposure to CYP2D6 substrates. Sertraline is metabolised by several enzymes with CYP2D6 contributing only partly, so the effect on sertraline is likely modest and may show up as more adverse effects.
What this interaction means in plain words
Givosiran and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Givosiran-related inhibition of CYP2D6 may modestly reduce sertraline clearance.
What to do
Monitor for sertraline adverse effects such as nausea, tremor or insomnia, and lower the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Sertraline?
MediHelp rates the interaction as minor. Givosiran and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can reduce CYP2D6 activity and raise exposure to CYP2D6 substrates. Sertraline is metabolised by several enzymes with CYP2D6 contributing only partly, so the effect on sertraline is likely modest and may show up as more adverse effects.
How serious is the interaction between Givosiran and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sertraline adverse effects such as nausea, tremor or insomnia, and lower the dose if they occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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