Drug interactions
Givosiran + Warfarin
Severity: Minor
Givosiran and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran reduces CYP1A2 and CYP2D6 activity, which may increase exposure to substrates. Warfarin's R-enantiomer is partly metabolized by CYP1A2, so the effect on INR is likely small.
What this interaction means in plain words
Givosiran and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givosiran belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Givosiran moderately reduces CYP1A2 activity, slightly slowing R-warfarin metabolism.
What to do
Check INR somewhat more often after starting givosiran and adjust warfarin if INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Givosiran with Warfarin?
MediHelp rates the interaction as minor. Givosiran and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran reduces CYP1A2 and CYP2D6 activity, which may increase exposure to substrates. Warfarin's R-enantiomer is partly metabolized by CYP1A2, so the effect on INR is likely small.
How serious is the interaction between Givosiran and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR somewhat more often after starting givosiran and adjust warfarin if INR changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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