Drug interactions
Glipizide + Insulin degludec-insulin aspart
Severity: Moderate
Glipizide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea produces additive glucose lowering and raises the risk of hypoglycemia, including severe episodes. The risk is greatest when therapy is started or intensified, or when meals are missed or renal function is reduced.
What this interaction means in plain words
Glipizide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: exogenous insulin lowers glucose while glipizide stimulates endogenous insulin secretion.
What to do
Monitor blood glucose closely and consider lowering the insulin or sulfonylurea dose when combining them. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Glipizide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with a sulfonylurea produces additive glucose lowering and raises the risk of hypoglycemia, including severe episodes. The risk is greatest when therapy is started or intensified, or when meals are missed or renal function is reduced.
How serious is the interaction between Glipizide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider lowering the insulin or sulfonylurea dose when combining them. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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