Drug interactions
Glipizide + Levoketoconazole
Severity: Moderate
Glipizide and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong inhibitor of CYP enzymes and may raise glipizide concentrations, increasing the risk of hypoglycemia. Levoketoconazole is also used in Cushing syndrome, where glucose levels may shift as cortisol falls.
What this interaction means in plain words
Glipizide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated glipizide metabolism by azole antifungal.
What to do
Monitor blood glucose closely when starting or stopping levoketoconazole. Reduce the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Glipizide with Levoketoconazole?
MediHelp rates the interaction as moderate. Glipizide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong inhibitor of CYP enzymes and may raise glipizide concentrations, increasing the risk of hypoglycemia. Levoketoconazole is also used in Cushing syndrome, where glucose levels may shift as cortisol falls.
How serious is the interaction between Glipizide and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping levoketoconazole. Reduce the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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