Drug interactions
Glipizide + Linagliptin
Severity: Moderate
Glipizide and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding linagliptin to a sulfonylurea such as glipizide raises the likelihood of hypoglycemia compared with the sulfonylurea alone. Linagliptin has little hypoglycemic risk by itself, but it adds to the sulfonylurea's effect.
What this interaction means in plain words
Glipizide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide belongs to Endocrine; Linagliptin belongs to Endocrine.
Why it happens
DPP-4 inhibition increases incretin levels, enhancing insulin secretion on top of sulfonylurea-stimulated release.
What to do
Consider reducing the glipizide dose when linagliptin is started. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Glipizide with Linagliptin?
MediHelp rates the interaction as moderate. Glipizide and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding linagliptin to a sulfonylurea such as glipizide raises the likelihood of hypoglycemia compared with the sulfonylurea alone. Linagliptin has little hypoglycemic risk by itself, but it adds to the sulfonylurea's effect.
How serious is the interaction between Glipizide and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when linagliptin is started. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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