Drug interactions
Glofitamab + Midazolam
Severity: Moderate
Glofitamab and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab triggers cytokine release, which can temporarily suppress CYP450 enzymes and raise exposure to sensitive substrates like midazolam. This is most relevant around the first doses and during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Cytokine-mediated transient suppression of CYP3A4 activity reduces midazolam clearance.
What to do
Monitor for increased or prolonged sedation during the period of cytokine release after glofitamab doses, and reduce midazolam dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Midazolam?
MediHelp rates the interaction as moderate. Glofitamab and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab triggers cytokine release, which can temporarily suppress CYP450 enzymes and raise exposure to sensitive substrates like midazolam. This is most relevant around the first doses and during cytokine release syndrome.
How serious is the interaction between Glofitamab and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased or prolonged sedation during the period of cytokine release after glofitamab doses, and reduce midazolam dose if needed.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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