Drug interactions
Glofitamab + Sirolimus
Severity: Moderate
Glofitamab and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that can temporarily suppress CYP3A activity. Sirolimus concentrations may therefore rise, especially during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP3A4 expression reduces sirolimus clearance.
What to do
Monitor sirolimus trough levels and toxicity during the initial glofitamab cycles and any cytokine release syndrome; reduce the sirolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glofitamab and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Sirolimus?
MediHelp rates the interaction as moderate. Glofitamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release that can temporarily suppress CYP3A activity. Sirolimus concentrations may therefore rise, especially during cytokine release syndrome.
How serious is the interaction between Glofitamab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels and toxicity during the initial glofitamab cycles and any cytokine release syndrome; reduce the sirolimus dose if levels rise.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
