Drug interactions
Glofitamab + Tacrolimus
Severity: Moderate
Glofitamab and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab triggers cytokine release, which can transiently suppress CYP450 enzyme activity. This may raise tacrolimus concentrations, particularly around first doses and during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity reduces tacrolimus clearance.
What to do
Monitor tacrolimus trough levels and renal function closely during the first cycles and any cytokine release syndrome. Reduce the tacrolimus dose if levels rise above target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Tacrolimus?
MediHelp rates the interaction as moderate. Glofitamab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab triggers cytokine release, which can transiently suppress CYP450 enzyme activity. This may raise tacrolimus concentrations, particularly around first doses and during cytokine release syndrome.
How serious is the interaction between Glofitamab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely during the first cycles and any cytokine release syndrome. Reduce the tacrolimus dose if levels rise above target.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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