Drug interactions
Glofitamab + Tizanidine
Severity: Moderate
Glofitamab and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that can temporarily suppress CYP enzyme activity. Tizanidine is a sensitive substrate of CYP1A2, so exposure may increase and cause hypotension and sedation, mainly around the first doses and during cytokine release syndrome.
What this interaction means in plain words
Glofitamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glofitamab belongs to Oncology; Tizanidine belongs to Musculoskeletal.
Why it happens
Cytokine-mediated transient suppression of CYP enzyme activity, decreasing tizanidine clearance.
What to do
Monitor blood pressure and sedation in the weeks after glofitamab initiation and during cytokine release syndrome. Consider holding or reducing tizanidine during these periods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Tizanidine?
MediHelp rates the interaction as moderate. Glofitamab and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab causes cytokine release that can temporarily suppress CYP enzyme activity. Tizanidine is a sensitive substrate of CYP1A2, so exposure may increase and cause hypotension and sedation, mainly around the first doses and during cytokine release syndrome.
How serious is the interaction between Glofitamab and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation in the weeks after glofitamab initiation and during cytokine release syndrome. Consider holding or reducing tizanidine during these periods.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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