Drug interactions
Glucagon + Insulin degludec-insulin aspart
Severity: Minor
Glucagon and Insulin degludec-insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes the effect of insulin. This is the basis for its use as a rescue treatment in insulin-induced hypoglycemia, but in other circumstances it can cause hyperglycemia and make glucose control harder.
What this interaction means in plain words
Glucagon and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, counteracting insulin's glucose-lowering action.
What to do
Use glucagon for severe hypoglycemia as intended, then check blood glucose and give oral carbohydrate once the patient is able to swallow. Review insulin dosing after any severe hypoglycemic event.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Insulin degludec-insulin aspart?
MediHelp rates the interaction as minor. Glucagon and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes the effect of insulin. This is the basis for its use as a rescue treatment in insulin-induced hypoglycemia, but in other circumstances it can cause hyperglycemia and make glucose control harder.
How serious is the interaction between Glucagon and Insulin degludec-insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use glucagon for severe hypoglycemia as intended, then check blood glucose and give oral carbohydrate once the patient is able to swallow. Review insulin dosing after any severe hypoglycemic event.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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