Drug interactions
Glucagon + Sotalol
Severity: Minor
Glucagon and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon has positive inotropic and chronotropic effects and is sometimes used for beta-blocker overdose. With sotalol it may cause a transient rise in heart rate and blood pressure, and the response may counteract the beta-blocker effect.
What this interaction means in plain words
Glucagon and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Sotalol belongs to Cardiovascular.
Why it happens
Glucagon increases cardiac cAMP through glucagon receptors, bypassing beta-receptor blockade and so opposing sotalol's effects.
What to do
No action is usually needed with routine glucagon use for hypoglycemia; monitor heart rate and blood pressure. Glucagon may be used intentionally for severe beta-blocker toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Sotalol?
MediHelp rates the interaction as minor. Glucagon and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon has positive inotropic and chronotropic effects and is sometimes used for beta-blocker overdose. With sotalol it may cause a transient rise in heart rate and blood pressure, and the response may counteract the beta-blocker effect.
How serious is the interaction between Glucagon and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed with routine glucagon use for hypoglycemia; monitor heart rate and blood pressure. Glucagon may be used intentionally for severe beta-blocker toxicity.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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