Drug interactions
Glycopyrronium + Prochlorperazine
Severity: Minor
Glycopyrronium and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has mild anticholinergic activity that can add to glycopyrronium, increasing dry mouth, constipation and urinary hesitancy. The effect is usually modest.
What this interaction means in plain words
Glycopyrronium and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycopyrronium belongs to Respiratory; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel and urinary function in susceptible patients; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Glycopyrronium with Prochlorperazine?
MediHelp rates the interaction as minor. Glycopyrronium and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine has mild anticholinergic activity that can add to glycopyrronium, increasing dry mouth, constipation and urinary hesitancy. The effect is usually modest.
How serious is the interaction between Glycopyrronium and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel and urinary function in susceptible patients; no routine dose change is needed.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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