Drug interactions
Goserelin + Lenvatinib
Severity: Moderate
Goserelin and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and goserelin may add to it. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Goserelin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG closely and correct hypokalemia, hypomagnesemia and hypocalcemia. Interrupt or reduce lenvatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Goserelin with Lenvatinib?
MediHelp rates the interaction as moderate. Goserelin and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and goserelin may add to it. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Goserelin and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG closely and correct hypokalemia, hypomagnesemia and hypocalcemia. Interrupt or reduce lenvatinib if QTc becomes markedly prolonged.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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