Drug interactions
Goserelin + Lopinavir
Severity: Moderate
Goserelin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT and PR intervals, and goserelin may add to QT prolongation. The combination may raise arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Goserelin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation from androgen deprivation (goserelin) and lopinavir effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor the QTc during combined therapy. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Goserelin with Lopinavir?
MediHelp rates the interaction as moderate. Goserelin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT and PR intervals, and goserelin may add to QT prolongation. The combination may raise arrhythmia risk, especially with other risk factors.
How serious is the interaction between Goserelin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during combined therapy. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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