Drug interactions
Goserelin + Mirtazapine
Severity: Moderate
Goserelin and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as goserelin can prolong the QT interval, and mirtazapine has a modest QT-prolonging effect. Combined use may increase the risk of arrhythmia in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Goserelin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization and mirtazapine has a weak effect on it.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Mirtazapine?
MediHelp rates the interaction as moderate. Goserelin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as goserelin can prolong the QT interval, and mirtazapine has a modest QT-prolonging effect. Combined use may increase the risk of arrhythmia in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Goserelin and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and repeat if other QT-prolonging drugs are added. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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