Drug interactions
Goserelin + Trazodone
Severity: Moderate
Goserelin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval, and trazodone also carries a QT-prolonging risk. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Goserelin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through androgen deprivation and trazodone effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium; monitor the QTc periodically and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Goserelin with Trazodone?
MediHelp rates the interaction as moderate. Goserelin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval, and trazodone also carries a QT-prolonging risk. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Goserelin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium; monitor the QTc periodically and avoid adding other QT-prolonging drugs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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