Drug interactions
Goserelin + Valbenazine
Severity: Moderate
Goserelin and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may cause modest QT prolongation at higher exposures, and goserelin can lengthen the QT interval through androgen suppression. Together they may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Goserelin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Goserelin belongs to Endocrine; Valbenazine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG and check electrolytes in patients with bradycardia, heart disease or congenital long QT. Monitor ECG if valbenazine dose is raised or CYP2D6/3A4 inhibitors are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Goserelin
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Goserelin with Valbenazine?
MediHelp rates the interaction as moderate. Goserelin and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may cause modest QT prolongation at higher exposures, and goserelin can lengthen the QT interval through androgen suppression. Together they may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Goserelin and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check electrolytes in patients with bradycardia, heart disease or congenital long QT. Monitor ECG if valbenazine dose is raised or CYP2D6/3A4 inhibitors are added.
What other medicines interact with Goserelin?
MediHelp also lists interactions of Goserelin with, for example, Amisulpride, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Goserelin page.
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