Drug interactions
Haloperidol + Leuprolide
Severity: Moderate
Haloperidol and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide may prolong the QT interval, and haloperidol has a similar effect. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Haloperidol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation; androgen suppression alters repolarization while haloperidol blocks hERG channels.
What to do
Obtain a baseline ECG and electrolytes and repeat the ECG periodically. Consider alternatives to haloperidol if the QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Haloperidol with Leuprolide?
MediHelp rates the interaction as moderate. Haloperidol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide may prolong the QT interval, and haloperidol has a similar effect. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Haloperidol and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat the ECG periodically. Consider alternatives to haloperidol if the QTc is markedly prolonged.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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