Drug interactions
Haloperidol + Pacritinib
Severity: Major
Haloperidol and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is primarily metabolized by CYP3A4 and pacritinib itself prolongs QT. Haloperidol also prolongs QT, so the more relevant concern is additive arrhythmia risk.
What this interaction means in plain words
Haloperidol and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Pacritinib belongs to Oncology.
Why it happens
Additive QT prolongation; haloperidol may also weakly inhibit CYP3A4-mediated pacritinib metabolism.
What to do
Avoid the combination if possible and monitor ECG and electrolytes if used together. Choose an antipsychotic with less QT effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Haloperidol with Pacritinib?
MediHelp rates the interaction as major. Haloperidol and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is primarily metabolized by CYP3A4 and pacritinib itself prolongs QT. Haloperidol also prolongs QT, so the more relevant concern is additive arrhythmia risk.
How serious is the interaction between Haloperidol and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and monitor ECG and electrolytes if used together. Choose an antipsychotic with less QT effect.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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