Drug interactions
Haloperidol + Prochlorperazine
Severity: Major
Haloperidol and Prochlorperazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and cause extrapyramidal symptoms. Combined use raises the risk of torsades de pointes and of dystonia, akathisia and neuroleptic malignant syndrome.
What this interaction means in plain words
Haloperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Haloperidol belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive hERG channel blockade and additive dopamine D2 antagonism.
What to do
Avoid the combination and use a non-dopamine-antagonist antiemetic such as ondansetron with caution regarding QT. If combined, monitor the ECG, electrolytes and for movement disorders.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Prochlorperazine?
MediHelp rates the interaction as major. Haloperidol and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval and cause extrapyramidal symptoms. Combined use raises the risk of torsades de pointes and of dystonia, akathisia and neuroleptic malignant syndrome.
How serious is the interaction between Haloperidol and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-dopamine-antagonist antiemetic such as ondansetron with caution regarding QT. If combined, monitor the ECG, electrolytes and for movement disorders.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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