Drug interactions
Haloperidol + Tucatinib
Severity: Moderate
Haloperidol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and can raise concentrations of CYP3A substrates including haloperidol. Higher haloperidol levels can increase QT prolongation, sedation and extrapyramidal effects.
What this interaction means in plain words
Haloperidol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing haloperidol metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and QTc prolongation, and consider lowering the haloperidol dose. Obtain an ECG if risk factors for QT prolongation are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Haloperidol with Tucatinib?
MediHelp rates the interaction as moderate. Haloperidol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a strong CYP3A inhibitor and can raise concentrations of CYP3A substrates including haloperidol. Higher haloperidol levels can increase QT prolongation, sedation and extrapyramidal effects.
How serious is the interaction between Haloperidol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QTc prolongation, and consider lowering the haloperidol dose. Obtain an ECG if risk factors for QT prolongation are present.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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