Drug interactions
Haloperidol + Vilazodone
Severity: Moderate
Haloperidol and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining vilazodone with haloperidol, a high-potency dopamine antagonist, may increase the risk of neuroleptic malignant syndrome and rarely serotonin syndrome. Both conditions are potentially life-threatening if not recognised early.
What this interaction means in plain words
Haloperidol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Haloperidol belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity with strong dopamine D2 antagonism, a pharmacodynamic interaction.
What to do
Monitor for fever, muscle rigidity, altered mental status, clonus and autonomic instability, particularly after dose changes. Stop both drugs and treat supportively if either syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Haloperidol with Vilazodone?
MediHelp rates the interaction as moderate. Haloperidol and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining vilazodone with haloperidol, a high-potency dopamine antagonist, may increase the risk of neuroleptic malignant syndrome and rarely serotonin syndrome. Both conditions are potentially life-threatening if not recognised early.
How serious is the interaction between Haloperidol and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for fever, muscle rigidity, altered mental status, clonus and autonomic instability, particularly after dose changes. Stop both drugs and treat supportively if either syndrome is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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