Drug interactions
Hawthorn + Mexiletine
Severity: Minor
Hawthorn and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hawthorn has cardioactive properties that could theoretically add to the electrophysiologic and hemodynamic effects of mexiletine. Clinical data are very limited.
What this interaction means in plain words
Hawthorn and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hawthorn belongs to Gastrointestinal Tract; Mexiletine belongs to Cardiovascular.
Why it happens
Theoretical additive cardiovascular pharmacodynamic effects; not established.
What to do
Monitor heart rate, blood pressure and ECG if hawthorn is used with mexiletine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Hawthorn
- Amiodarone + Hawthorn Moderate
- Digoxin + Hawthorn Moderate
- Disopyramide + Hawthorn Moderate
- Encainide + Hawthorn Moderate
- Hawthorn + Ibutilide Moderate
- Hawthorn + Procainamide Moderate
Frequently asked questions
Can I take Hawthorn with Mexiletine?
MediHelp rates the interaction as minor. Hawthorn and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hawthorn has cardioactive properties that could theoretically add to the electrophysiologic and hemodynamic effects of mexiletine. Clinical data are very limited.
How serious is the interaction between Hawthorn and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG if hawthorn is used with mexiletine.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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