Drug interactions
Hemin + Methylprednisolone
Severity: Moderate
Hemin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can induce hepatic delta-aminolevulinic acid synthase, the enzyme that hemin is given to suppress in acute porphyria. This could reduce the benefit of hemin or precipitate porphyria attacks.
What this interaction means in plain words
Hemin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hemin belongs to Miscellaneous; Methylprednisolone belongs to Endocrine.
Why it happens
Glucocorticoids may induce ALA synthase, opposing the feedback repression by hemin.
What to do
Avoid corticosteroids in patients with acute porphyria unless essential, and monitor porphyrin precursors and clinical response if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Hemin
- Hemin + Secobarbital Major
- Argatroban + Hemin Moderate
- Bazedoxifene-conjugated estrogens + Hemin Moderate
- Dabigatran etexilate + Hemin Moderate
- Dalteparin + Hemin Moderate
- Desogestrel-ethinyl estradiol + Hemin Moderate
Frequently asked questions
Can I take Hemin with Methylprednisolone?
MediHelp rates the interaction as moderate. Hemin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can induce hepatic delta-aminolevulinic acid synthase, the enzyme that hemin is given to suppress in acute porphyria. This could reduce the benefit of hemin or precipitate porphyria attacks.
How serious is the interaction between Hemin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid corticosteroids in patients with acute porphyria unless essential, and monitor porphyrin precursors and clinical response if they are used.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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