Drug interactions
Human papillomavirus vaccine + Sirolimus
Severity: Moderate
Human papillomavirus vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus suppresses T-cell responses and may reduce vaccine effectiveness. The HPV vaccine is non-live and may be given, though protection may be reduced.
What this interaction means in plain words
Human papillomavirus vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Human papillomavirus vaccine belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition suppresses lymphocyte proliferation and immune response to antigen.
What to do
Vaccinate before transplantation or immunosuppression if feasible; otherwise follow immunocompromised schedules and do not withhold the vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus suppresses T-cell responses and may reduce vaccine effectiveness. The HPV vaccine is non-live and may be given, though protection may be reduced.
How serious is the interaction between Human papillomavirus vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before transplantation or immunosuppression if feasible; otherwise follow immunocompromised schedules and do not withhold the vaccine.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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