Drug interactions
Hydrochlorothiazide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Hydrochlorothiazide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding separate hydrochlorothiazide duplicates the thiazide component. This can lead to excessive diuresis, hypotension, hyponatremia, hypokalemia and impaired renal function.
What this interaction means in plain words
Hydrochlorothiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to additive thiazide-induced sodium and potassium loss and volume depletion.
What to do
Avoid concurrent separate hydrochlorothiazide and use only the dose provided by the combination product. If dose adjustment is needed, change the combination or switch to irbesartan alone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding separate hydrochlorothiazide duplicates the thiazide component. This can lead to excessive diuresis, hypotension, hyponatremia, hypokalemia and impaired renal function.
How serious is the interaction between Hydrochlorothiazide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent separate hydrochlorothiazide and use only the dose provided by the combination product. If dose adjustment is needed, change the combination or switch to irbesartan alone.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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