Drug interactions
Hydrochlorothiazide + Indacaterol
Severity: Moderate
Hydrochlorothiazide and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, and the effect may be additive. Hypokalemia can promote cardiac arrhythmias, particularly in patients with cardiac disease or other risk factors.
What this interaction means in plain words
Hydrochlorothiazide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Beta-2 agonists shift potassium into cells while thiazide diuretics increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium periodically, especially at initiation and in patients with heart disease or hypoxia. Replace potassium or magnesium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Indacaterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, and the effect may be additive. Hypokalemia can promote cardiac arrhythmias, particularly in patients with cardiac disease or other risk factors.
How serious is the interaction between Hydrochlorothiazide and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at initiation and in patients with heart disease or hypoxia. Replace potassium or magnesium if levels fall.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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