Drug interactions
Hydrochlorothiazide + Insulin degludec-insulin aspart
Severity: Moderate
Hydrochlorothiazide and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may reduce the effectiveness of insulin in people with diabetes. Glycemic control can deteriorate, particularly at higher doses or when potassium falls.
What this interaction means in plain words
Hydrochlorothiazide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Thiazides cause hypokalemia and reduced insulin secretion and sensitivity, producing a pharmacodynamic antagonism of insulin.
What to do
Monitor blood glucose and serum potassium when starting or changing the diuretic dose. Adjust the insulin dose as needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and may reduce the effectiveness of insulin in people with diabetes. Glycemic control can deteriorate, particularly at higher doses or when potassium falls.
How serious is the interaction between Hydrochlorothiazide and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when starting or changing the diuretic dose. Adjust the insulin dose as needed and correct hypokalemia.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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