Drug interactions
Hydrochlorothiazide + Penicillin g
Severity: Minor
Hydrochlorothiazide and Penicillin g: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both penicillin G and thiazides are secreted by renal tubular organic anion transporters, so they may compete for elimination. The clinical effect is generally small, although penicillin levels may rise modestly. Thiazide-induced hypokalemia may also matter with high-dose penicillin G.
What this interaction means in plain words
Hydrochlorothiazide and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Penicillin g belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No routine adjustment is needed; monitor renal function and electrolytes in patients receiving high-dose penicillin G.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Penicillin g, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Penicillin g?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Penicillin g have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both penicillin G and thiazides are secreted by renal tubular organic anion transporters, so they may compete for elimination. The clinical effect is generally small, although penicillin levels may rise modestly. Thiazide-induced hypokalemia may also matter with high-dose penicillin G.
How serious is the interaction between Hydrochlorothiazide and Penicillin g?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and electrolytes in patients receiving high-dose penicillin G.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
