Drug interactions
Hydrochlorothiazide + Tiotropium-olodaterol
Severity: Moderate
Hydrochlorothiazide and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide causes renal potassium loss and olodaterol can lower potassium by cellular uptake. The combination may cause hypokalemia and raise arrhythmia risk.
What this interaction means in plain words
Hydrochlorothiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive potassium lowering through diuretic-induced loss and beta2-mediated cellular shift.
What to do
Monitor serum potassium periodically and replace as needed. Take particular care in patients with heart disease or on digoxin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide causes renal potassium loss and olodaterol can lower potassium by cellular uptake. The combination may cause hypokalemia and raise arrhythmia risk.
How serious is the interaction between Hydrochlorothiazide and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace as needed. Take particular care in patients with heart disease or on digoxin.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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