Drug interactions
Hydrochlorothiazide + Vitamin d
Severity: Moderate
Hydrochlorothiazide and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, and vitamin D increases intestinal calcium absorption. Together they can cause hypercalcemia, particularly with high vitamin D doses or active analogs or in patients with renal impairment.
What this interaction means in plain words
Hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazide-enhanced renal calcium reabsorption combined with vitamin D-mediated increased calcium absorption produces additive elevation of serum calcium.
What to do
Monitor serum calcium periodically, especially at the start of therapy and after dose increases. Reduce the vitamin D dose or stop the thiazide if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Vitamin d
Frequently asked questions
Can I take Hydrochlorothiazide with Vitamin d?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, and vitamin D increases intestinal calcium absorption. Together they can cause hypercalcemia, particularly with high vitamin D doses or active analogs or in patients with renal impairment.
How serious is the interaction between Hydrochlorothiazide and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially at the start of therapy and after dose increases. Reduce the vitamin D dose or stop the thiazide if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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