Drug interactions
Hydrochlorothiazide-irbesartan + Midodrine
Severity: Moderate
Hydrochlorothiazide-irbesartan and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established interaction exists through renal competition. Pharmacodynamically, midodrine raises blood pressure and opposes the antihypertensive drugs, which is an expected opposing effect rather than a kinetic one.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism: alpha-1 agonist vasopressor effect opposes antihypertensive therapy.
What to do
Monitor blood pressure, including supine readings, and reassess the need for both agents. Adjust doses to the blood pressure target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Midodrine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. No well-established interaction exists through renal competition. Pharmacodynamically, midodrine raises blood pressure and opposes the antihypertensive drugs, which is an expected opposing effect rather than a kinetic one.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and reassess the need for both agents. Adjust doses to the blood pressure target.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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