Drug interactions
Hydrochlorothiazide-irbesartan + Vadadustat
Severity: Moderate
Hydrochlorothiazide-irbesartan and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat is a substrate of renal organic anion transporters, and irbesartan may inhibit OAT1/OAT3, which could raise vadadustat exposure. This may lead to an excessive or too rapid rise in hemoglobin with associated cardiovascular and thrombotic risk.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT1/OAT3-mediated renal transport reduces vadadustat clearance and increases its exposure.
What to do
Monitor hemoglobin regularly and reduce the vadadustat dose if the rise is too rapid or exceeds target. Watch for adverse effects such as hypertension and thrombosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Vadadustat?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is a substrate of renal organic anion transporters, and irbesartan may inhibit OAT1/OAT3, which could raise vadadustat exposure. This may lead to an excessive or too rapid rise in hemoglobin with associated cardiovascular and thrombotic risk.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and reduce the vadadustat dose if the rise is too rapid or exceeds target. Watch for adverse effects such as hypertension and thrombosis.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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