Drug interactions
Hydrochlorothiazide-irbesartan + Vitamin d
Severity: Moderate
Hydrochlorothiazide-irbesartan and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and combined with vitamin D supplementation this can raise serum calcium and occasionally cause hypercalcemia. Risk is higher with high vitamin D doses, calcium supplements or renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase distal tubular calcium reabsorption while vitamin D increases intestinal calcium absorption, producing additive increases in serum calcium.
What to do
Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Vitamin d
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Vitamin d?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and combined with vitamin D supplementation this can raise serum calcium and occasionally cause hypercalcemia. Risk is higher with high vitamin D doses, calcium supplements or renal impairment.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high-dose vitamin D or calcium supplements. Reduce the vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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