Drug interactions
Hydrochlorothiazide-lisinopril + Toremifene
Severity: Moderate
Hydrochlorothiazide-lisinopril and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazides reduce urinary calcium excretion. The combination increases the risk of clinically significant hypercalcemia. Toremifene's labeling advises caution with drugs that decrease renal calcium excretion.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Toremifene belongs to Endocrine.
Why it happens
Thiazide-reduced renal calcium excretion adds to toremifene-associated hypercalcemia.
What to do
Monitor serum calcium regularly, especially early in treatment. Consider an alternative antihypertensive if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-lisinopril and Toremifene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Toremifene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene can cause hypercalcemia, particularly in patients with bone metastases, and thiazides reduce urinary calcium excretion. The combination increases the risk of clinically significant hypercalcemia. Toremifene's labeling advises caution with drugs that decrease renal calcium excretion.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium regularly, especially early in treatment. Consider an alternative antihypertensive if hypercalcemia develops.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
