Drug interactions
Hydromorphone + Metoclopramide
Severity: Moderate
Hydromorphone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydromorphone slows gastrointestinal transit, opposing metoclopramide, and both drugs can cause sedation. The combination may increase drowsiness and reduce the antiemetic or prokinetic benefit.
What this interaction means in plain words
Hydromorphone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Opposing effects on gut motility and additive CNS depression.
What to do
Monitor sedation and respiratory rate, and assess response of nausea or gastric stasis. Adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Hydromorphone with Metoclopramide?
MediHelp rates the interaction as moderate. Hydromorphone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydromorphone slows gastrointestinal transit, opposing metoclopramide, and both drugs can cause sedation. The combination may increase drowsiness and reduce the antiemetic or prokinetic benefit.
How serious is the interaction between Hydromorphone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and assess response of nausea or gastric stasis. Adjust doses as needed.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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