Drug interactions
Hydroxychloroquine + Insulin degludec-insulin aspart
Severity: Moderate
Hydroxychloroquine and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin or other antidiabetic drugs. Insulin requirements may fall after it is started.
What this interaction means in plain words
Hydroxychloroquine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Hydroxychloroquine may enhance insulin sensitivity and reduce insulin degradation; the exact mechanism is not fully established.
What to do
Monitor blood glucose more often after starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Warn the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin or other antidiabetic drugs. Insulin requirements may fall after it is started.
How serious is the interaction between Hydroxychloroquine and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often after starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Warn the patient about hypoglycemia symptoms.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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