Drug interactions
Hydroxychloroquine + Mirtazapine
Severity: Moderate
Hydroxychloroquine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been linked to QT prolongation, mainly in overdose or in patients with risk factors, and hydroxychloroquine can add to this effect. The combined risk of arrhythmia is generally modest but meaningful in vulnerable patients.
What this interaction means in plain words
Hydroxychloroquine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive effects on ventricular repolarization causing QT prolongation.
What to do
Obtain a baseline ECG in patients with cardiac disease or other QT risk factors, keep potassium and magnesium normal, and reassess if the QTc rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Mirtazapine?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has been linked to QT prolongation, mainly in overdose or in patients with risk factors, and hydroxychloroquine can add to this effect. The combined risk of arrhythmia is generally modest but meaningful in vulnerable patients.
How serious is the interaction between Hydroxychloroquine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac disease or other QT risk factors, keep potassium and magnesium normal, and reassess if the QTc rises.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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